Vitamin K2维生素 K2

K1 vs K2

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K1 与 K2 · 姐妹分工

Vitamin K is a family that shares the same core (2-methyl-1,4-naphthoquinone head) but differs in tail length:

K1 (phylloquinone): single isoprenoid side chain, comes from leafy greens — it's literally part of the chlorophyll synthesis machinery. The liver takes it up to synthesize clotting factors II / VII / IX / X (γ-carboxylated so they can bind Ca²⁺ and start coagulation). Healthy people rarely lack K1 — leafy greens are everywhere.K2 (menaquinones, MK-n): multi-isoprenoid side chain where n is the unit count, commonly MK-4 through MK-13. Sources are fermented foods and gut microbial conversion. K2 routes to bone and blood vessels — the lead character of extra-hepatic vitamin K-dependent proteins (VKDPs).K3 (menadione): synthetic form without a side chain; hepatotoxic, so not usable as a human supplement — only animal feed and research.
So today's discussion of 'K2 prevents osteoporosis and arterial calcification' is almost never about coagulation — that's K1's territory.

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本站提供科普与一般性建议，不替代医师诊断或处方；有症状或正在服药请咨询合格医师。 Educational content, not medical advice — consult a clinician for diagnosis or treatment.

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Vitamin K2维生素 K2

K1 vs K2

Stop 1/6

K1 与 K2 · 姐妹分工

Vitamin K is a family that shares the same core (2-methyl-1,4-naphthoquinone head) but differs in tail length:

K1 (phylloquinone): single isoprenoid side chain, comes from leafy greens — it's literally part of the chlorophyll synthesis machinery. The liver takes it up to synthesize clotting factors II / VII / IX / X (γ-carboxylated so they can bind Ca²⁺ and start coagulation). Healthy people rarely lack K1 — leafy greens are everywhere.K2 (menaquinones, MK-n): multi-isoprenoid side chain where n is the unit count, commonly MK-4 through MK-13. Sources are fermented foods and gut microbial conversion. K2 routes to bone and blood vessels — the lead character of extra-hepatic vitamin K-dependent proteins (VKDPs).K3 (menadione): synthetic form without a side chain; hepatotoxic, so not usable as a human supplement — only animal feed and research.
So today's discussion of 'K2 prevents osteoporosis and arterial calcification' is almost never about coagulation — that's K1's territory.

Read story

本站提供科普与一般性建议，不替代医师诊断或处方；有症状或正在服药请咨询合格医师。 Educational content, not medical advice — consult a clinician for diagnosis or treatment.