The claimEvidence A · guideline-tier
Aspirin 60+ for primary cardiovascular prevention
The evidence
USPSTF 2022 withdrew the 60+ recommendation — bleeding risk outweighs CVD benefit (net harm).
The mechanism, in brief
The heart needs ATP, electrolytes, and oxygen. K⁺/Na⁺/Mg²⁺/Ca²⁺ run excitation-contraction coupling; iron delivers oxygen.
Sources (4)
- National Institutes of Health, Office of Dietary Supplements. (2021). Potassium — Fact Sheet for Health Professionals.
- National Institutes of Health, Office of Dietary Supplements. (2022). Magnesium — Fact Sheet for Health Professionals.
- National Institutes of Health, Office of Dietary Supplements. (2024). Calcium — Fact Sheet for Health Professionals.
- National Institutes of Health, Office of Dietary Supplements. (2024). Iron — Fact Sheet for Health Professionals.