The claimEvidence A · guideline-tier
GLP-1 is a miracle weight-loss shot for everyone
The evidence
STEP-1 indication is BMI≥30 (or ≥27+comorbidity); ~2/3 weight returns within a year of stopping (STEP-4).
The mechanism, in brief
Type 2 diabetes (T2D) = chronic hyperglycemia caused by insulin resistance + relatively insufficient secretion. Distinct from T1D, which is autoimmune β-cell destruction → absolute insulin deficiency.
Sources (2)
- American Diabetes Association. (2024). Standards of Medical Care in Diabetes — 2024. Diabetes Care, 47(Suppl. 1).
- Wang, L., Gao, P., Zhang, M., Huang, Z., Zhang, D., Deng, Q., et al. (2017). Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA, 317(24), 2515-2523.