The claimEvidence C · limited
Lion's Mane regrows neurons
The evidence
NGF upregulation is in cell + rodent models only; human cognition data is small short-term RCTs.
The mechanism, in brief
Lion's Mane = Hericium erinaceus — a white / cream filamentous fungal cluster:
Sources (1)
- Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R. P., Kuppusamy, U. R., et al. (2013). Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539-554. Erinacines and hericenones cross the BBB in animals and stimulate NGF/BDNF expression in cultured neurons.