The claimEvidence A · guideline-tier
Statins deplete CoQ10, so CoQ10 fixes statin muscle pain
The evidence
The mechanism is real (mevalonate pathway), but a 6-RCT / 302-person meta shows CoQ10 doesn't reliably relieve the myalgia (Banach 2015).
The mechanism, in brief
Two contrasting examples help you tell 'top it up' from 'just separate the timing'.
Sources (2)
- Wiesner, A., Gajewska, D., & Pasko, P. (2021). Levothyroxine interactions with food and dietary supplements - a systematic review. Pharmaceuticals, 14(3), 206. Calcium, iron, and coffee reduce levothyroxine absorption (iron co-ingestion about 33%, coffee about 27-36%); guidance advises an empty stomach and at least 4 hours separation.
- Banach, M., Serban, C., Sahebkar, A., et al. (2015). Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. Mayo Clinic Proceedings, 90(1), 24-34. Across 6 RCTs (302 patients), CoQ10 supplementation produced no significant improvement in statin-associated muscle pain or plasma creatine kinase.