Collagen peptides胶原蛋白肽 Collagen Peptides

Place · Level 3 · Supplement

吃啥补啥最经典误区 · vitamin C 才是真协同 · 关节、皮肤 B 级证据 · 营销 ≫ 证据

Triple helix

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身份 · 三股螺旋

Collagen is the body's most abundant protein — about 25–30% of total protein. It forms structural scaffolds in skin, bone, cartilage, tendons, ligaments, vessel walls, and sclera.

Its structure is distinctive: a right-handed helix of three α chains, each a repeating (Gly-X-Y)ₙ sequence where:

Glycine (Gly) occupies every third amino acid position — only Gly's tiny side chain fits the center of the helixX position: often proline (Pro)Y position: often hydroxyproline (Hyp) — a post-translational modification adding an -OH to Pro, and this step requires vitamin C as a cofactor
Collagen peptides = partly hydrolyzed collagen — heat plus enzymatic cleavage break the large triple helix into 2–10 kDa short peptides (5–30 amino acids). These short peptides form a gel when cooled (gelatin); further hydrolysis yields cold-water-soluble collagen peptide powder — the form sold by Vital Proteins, Great Lakes, NeoCell, etc.

Practical difference between the two product forms:

Gelatin: partly hydrolyzed; forms a gel in cold water; used in cooking (jellies, mousses) and can be taken orallyCollagen peptide (hydrolyzed collagen): further-hydrolyzed short peptides; dissolves in cold or hot water; no gel feel
The amino acid composition of the two is essentially identical — both are Gly + Pro + Hyp-rich mixtures with 90%+ total protein content. The marketing difference is mainly 'easy-dissolve vs cooking-use', not 'bioactive potency'.

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