Biotin生物素 B7

Carboxylase cofactor

Stop 1/5

羧化酶辅因子

B7 is the shared cofactor for four critical carboxylases — it works by being covalently bound to a lysine residue on the enzyme:

1. Pyruvate carboxylase: pyruvate → oxaloacetate → enters gluconeogenesis (producing glucose during fasting or low-carb states)
2. Acetyl-CoA carboxylase (ACC): acetyl-CoA → malonyl-CoA → the first committed step of de novo fatty acid synthesis; also regulates fatty acid oxidation via malonyl-CoA (which inhibits CPT1)
3. 3-methylcrotonyl-CoA carboxylase (MCC): leucine catabolism
4. Propionyl-CoA carboxylase (PCC): metabolism of odd-chain fatty acids and branched-chain amino acids

These four pathways span glucose metabolism, lipid metabolism, and amino acid metabolism — which is why B7 is such a foundational nutrient.

Read story Open mechanism

本站提供科普与一般性建议，不替代医师诊断或处方；有症状或正在服药请咨询合格医师。 Educational content, not medical advice — consult a clinician for diagnosis or treatment.

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Biotin生物素 B7

Carboxylase cofactor

Stop 1/5

羧化酶辅因子

B7 is the shared cofactor for four critical carboxylases — it works by being covalently bound to a lysine residue on the enzyme:

1. Pyruvate carboxylase: pyruvate → oxaloacetate → enters gluconeogenesis (producing glucose during fasting or low-carb states)
2. Acetyl-CoA carboxylase (ACC): acetyl-CoA → malonyl-CoA → the first committed step of de novo fatty acid synthesis; also regulates fatty acid oxidation via malonyl-CoA (which inhibits CPT1)
3. 3-methylcrotonyl-CoA carboxylase (MCC): leucine catabolism
4. Propionyl-CoA carboxylase (PCC): metabolism of odd-chain fatty acids and branched-chain amino acids

These four pathways span glucose metabolism, lipid metabolism, and amino acid metabolism — which is why B7 is such a foundational nutrient.

Read story Open mechanism

本站提供科普与一般性建议，不替代医师诊断或处方；有症状或正在服药请咨询合格医师。 Educational content, not medical advice — consult a clinician for diagnosis or treatment.