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Debunking Matrix
The claimEvidence B · meta-analysis

Oral hyaluronic acid / collagen rejuvenates skin

The evidence

Oral HA is broken down in the gut; topical / injected delivery is the only route with skin endpoint data.

The mechanism, in brief

Collagen is the body's most abundant protein — about 25–30% of total protein. It forms structural scaffolds in skin, bone, cartilage, tendons, ligaments, vessel walls, and sclera.

Sources (1)
  • Khatri, M., Naughton, R. J., Clifford, T., Harper, L. D., & Corr, L. (2021). The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids, 53(10), 1493-1506.
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