营销话术证据 B · meta 分析
转氨酶降下来了，就说明肝养好了
真相
转氨酶是肝细胞破裂后漏进血里的酶，它读的是漏出量不是功能；终末期无细胞可漏时反而正常，而且它本身会波动，任何前后两次抽血都可能显示下降。
机制速览
几乎所有护肝片的宣传最后都落在同一句话上: 吃完转氨酶降了。这个指标值得单独讲一幕, 因为它测的东西和大多数人以为的不是一回事。
来源（3）
- National Institute of Diabetes and Digestive and Kidney Diseases. (2020). Milk Thistle. In LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Human trials in chronic liver disease have been 'promising but inconclusive'; milk thistle itself has not been implicated in serum enzyme elevations or clinically apparent liver injury (likelihood score E); intravenous purified silybinin is approved in Europe for Amanita phalloides poisoning.
- Fried, M. W., Navarro, V. J., Afdhal, N., Belle, S. H., Wahed, A. S., Hawke, R. L., et al. (2012). Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. JAMA, 308(3), 274-282. SyNCH trial, N=154, silymarin 420 or 700 mg three times daily × 24 weeks vs placebo: no significant difference in decline of serum ALT and no difference in HCV RNA — higher-than-customary doses did not help.
- Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., et al. (2018). The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology, 67(1), 328-357.