营销话术证据 C · 证据有限

抑酸药 (PPI) 会偷走你的钙、让你骨质疏松

PPI → 钙/铁 机制说得通但证据弱、有争议；真正确证的是长期用相关的低镁 (FDA 2011) 和 B12 偏低。

真相

PPI → 钙/铁机制说得通但证据弱、有争议；真正确证的是长期用相关的低镁 (FDA 2011) 和 B12 偏低。

机制速览

同一个道理——营养素的吸收或保留, 靠身体里一个具体条件; 药改了那个条件, 营养素就出问题——换到别的器官也成立。

来源（2）

U.S. Food and Drug Administration. (2011). FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of Proton Pump Inhibitor drugs (PPIs).
Lam, J. R., Schneider, J. L., Zhao, W., & Corley, D. A. (2013). Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA, 310(22), 2435-2442. In a large case-control study, two or more years of PPI use was associated with increased risk of vitamin B12 deficiency.